Dear All
This article and accompanying paper (by Gu and coworkers) talk about how the deadly botolium neurotoxin is kept protected in the host gastrointestinal tract by another structurally similar protein. All three domains of the two proteins are remarkably similar and they dimerise in a pH dependent manner. Gu and coworkers demonstrate that the mutations of residues at the interchain interface, that form four crucial salt bridges, render them incapable of dimerisation.
URL to the article:
Botulinum neurotoxin must form a complex with a structurally similar protein tosurvive in the gastrointestinal tract. http://www.sciencemag.org/cgi/content/summary/335/6071/928<http://app.aaas-science.org/e/er?s=1906&lid=12360&elq=3b1e5847af4a4432beae97e9ea14fe05>
Sowdhamini
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